Muristerone A is a potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. An analog of ecdysone with similar properties to Ponasterone A. Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Induces apoptosis in cells transfected with wild-type Bax. Induces expression of beta-galactosidase. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest. Major molting hormone in some insects. Has protective effects in plants. Source: Ipomoea hederacea seeds Synonyms: 2beta,3beta,5beta,11alpha,14alpha,20R,22R-Heptahydroxycholest-7-en-6-one CAS Number: 38778-30-2 Molecular Weight: 496.6 Molecular Formula: C27H44O8 Method for Determining Identity: Proton NMR Appearance: Supplied as a white to off-white solid. Purity: 95% (HPLC) Solubility: Soluble in acetic acid, ethanol, methanol or DMSO. Insoluble in water. Usage: To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg muristerone A (2umol). Gently mix to dissolve the product (5 to 10min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at 4C or at -20C. Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
496.6
Purity:
95% (HPLC)
Form:
Supplied as a white to off-white solid.
CAS Number:
[38778-30-2]
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