Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor. Anti-obesity and antihypercholesterolemic compound. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN). Anti-proliferative. Causes cell cycle arrest at G1 phase. Apoptosis inducer through caspase-3 activation. Sn-1-selective-diacylglycerol lipases alpha (DAGLalpha) inhibitor. Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Source: Synthetic. Originally isolated from Streptomyces sp. Synonyms: Tetrahydrolipstatin, Xenical, Alli, Ro-18-0647 CAS Number: 96829-58-2 Molecular Weight: 495.7 Molecular Formula: C29H53NO5 Appearance: Supplied as a white to off-white solid. Purity: 98% (HPLC) Solubility: DMSO, Ethanol, DMF Method for Determining Identity: HPLC and IR Storage and Stability: May be stored at 4C for short-term only. Stable for 12 months after receipt when stored at -20C. Protect from light and moisture. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
495.7
Purity:
98% (HPLC)
Form:
Supplied as a white to off-white solid.
CAS Number:
[96829-58-2]
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