Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. Synonyms: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one CAS Number: 872573-93-8 Molecular Weight: 351.5 Molecular Formula: C18H13N3OS2 Appearance: Supplied as a brown solid. Purity: 95% (NMR) Solubility: DMSO Storage and Stability: Store at 4C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molecular Weight:
351.5
Purity:
95% (NMR)
Form:
Supplied as a brown solid.
CAS Number:
[872573-93-8]
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