Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal. Synonyms: (S-(R*,R*-(E,E)))-Sclerotiorin, 7-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6H-2-benzopyran-6,8(7H)-dione CAS Number: 549-23-5 Source: Fungus Penicillium sp. Molecular Formula: C21H23ClO5 Molecular Weight: 390.9 Method for Determining Identity: Proton NMR Appearance: Supplied as a yellow solid. Purity: 97% (HPLC) Solubility: DMSO, ethanol or DMF. Sparingly soluble in aqueous buffers. Solubility in Aqueous Buffers: Dissolve in DMF and then dilute with the aqueous buffer of choice. Sclerotiorin has a solubility of ~0.3mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
390.9
Purity:
97% (HPLC)
Form:
Supplied as a yellow solid.
CAS Number:
[549-23-5]
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