IL-17RB, Recombinant, Human, hIgG-His-Tag, aa18-292

Product Overview

• Article Name: IL-17RB, Recombinant, Human, hIgG-His-Tag, aa18-292
• Biozol Catalog Number: USB-045986
• Supplier Catalog Number: 045986
• Alternative Catalog Number: USB-045986-10,USB-045986-20,USB-045986-50,USB-045986-100,USB-045986-250
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

IL-17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C. It has been shown to mediate the activation of NFkappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL-17RB, fused to hIgG-His-Tag at C-terminal, was expressed in insect cell and purified by using conventional chromatography techniques. Recombinant protein corresponding to aa18-292 from human IL-17RB, fused to hIgG-His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~57.3kD (514aa) Amino Acid Sequence: REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP Biological Activity: Measured by its binding ability in a functional ELISA with human IL25, the ED50 range is 2ug/ml. Applications: Suitable for use in SDS-PAGE, Bioactivity. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 57.3
• NCBI: 061195
• UniProt: Q9NRM6
• Purity: 85% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.