HYAL2 (Hyaluronoglucosaminidase-2, Lung carcinoma protein 2), Rabbit
Biozol Catalog Number:
USB-144712
Supplier Catalog Number:
144712
Alternative Catalog Number:
USB-144712-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
WB
Immunogen:
Synthetic peptide corresponding to aa142-157, VRNWQDKDVYRRLSRQ, at the C-terminal of human HYAL2, different from the related rat and mouse sequences by three amino acids. Species Homology: mouse
HYAL2(hyaluronoglucosaminidase 2) also known as hyaluronidase 2, LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that HYAL2 was expressed in all human tissues tested except adult brain, and Western blot analysis detected Hyal2protein in all mouse tissues examined except adult brain. The HYAL2 gene is mapped on 3p21.31. HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus (JSRV). The findings of Rai et al. (2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation. UniProt Number: Q12891 Gene ID: HYAL2 Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20°C for one year. After reconstitution, store at 4°C for one month. Can also be aliquoted and stored frozen at -20°C for long term. Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
