| Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3beta, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-gamma, Cdk3/cyclin E, Erk1, PKCgamma, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCalpha respectively.) Inhibits NF-kappaB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48uM respectively). Synonyms: (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one, SK&F 108752 CAS Number: 82005-12-7 Molecular Weight: 324.13 Molecular Formula: C11H10BrN5O2 Solubility: DMSO to 10mM Method for Determining Identity: Proton NMR Appearance: Supplied as a yellow solid. Purity: ~97% (HPLC) Storage and Stability: Store at -20C under inert atmosphere. This product is light sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
