BMS 303141 (ATP Citrate Lyase Inhibitor, Orally Bioavailable, 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1-biphenyl]-3-yl)-benzenesulfonamide), CAS [[943962-47-8]]

Product Overview

• Article Name: BMS 303141 (ATP Citrate Lyase Inhibitor, Orally Bioavailable, 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1-biphenyl]-3-yl)-benzenesulfonamide), CAS [[943962-47-8]]
• Biozol Catalog Number: USB-145663
• Supplier Catalog Number: 145663
• Alternative Catalog Number: USB-145663-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

ATP citrate lyase (ACL) inhibitor (IC50 = 0.13um for human recombinant ACL), blocks lipid synthesis (IC50 = 8um in HepG2 cells). Displays no cytotoxicity up to a concentration of 50um. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable. Sequence: C19H15Cl2NO4S Solubility: DMSO (~10mM), Ethanol (~50mM) Molecular Weight: ~424.3 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 424.3
• Purity: ~99% (HPLC)
• Form: Supplied as a white crystalline solid.
• CAS Number: [943962-47-8]