CID 2858522 (Selectively Inhibits PKC-induced NF-kB Activation, 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd roxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dime thyl-1H-benzimidazol-1-yl]ethanone), CAS [[758679-97-9]]

Product Overview

• Article Name: CID 2858522 (Selectively Inhibits PKC-induced NF-kB Activation, 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd roxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dime thyl-1H-benzimidazol-1-yl]ethanone), CAS [[758679-97-9]]
• Biozol Catalog Number: USB-145668
• Supplier Catalog Number: 145668
• Alternative Catalog Number: USB-145668-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Selectively inhibits protein kinase C (PKC)-induced activation of the NF-kappaB pathway (IC50 < 0.1um for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-kappaB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-kappaB pathways, including that activated by tumor necrosis factor (TNF). Sequence: C28H39N3O3 Solubility: DMSO (~20mM), Ethanol (~20mM) Molecular Weight: ~465.63 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 465.63
• Purity: ~98% (HPLC)
• Form: Supplied as a pale yellow solid.
• CAS Number: [758679-97-9]