KC7F2 (N,N-(Dithiodi-2,1-ethanediyl)bis[2, 5-dichlorobenzenesulfonamide), CAS [[927822-86-4]]

Product Overview

• Article Name: KC7F2 (N,N-(Dithiodi-2,1-ethanediyl)bis[2, 5-dichlorobenzenesulfonamide), CAS [[927822-86-4]]
• Biozol Catalog Number: USB-145680
• Supplier Catalog Number: 145680
• Alternative Catalog Number: USB-145680-10,USB-145680-50
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Inhibitor of HIF-1alpha. Thought to act via down-regulation of HIF-1alpha protein synthesis, reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1alpha accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2. Sequence: C16H16Cl4N2O4S4 Solubility: DMSO (~100mM) Molecular Weight: ~570.38 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 570.38
• Purity: ~98% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [927822-86-4]