PD 0332991 Isethionate (6-acetyl-8-cyclopentyl-5-methyl-2-[ [5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d] pyrimidin-7(8H)-one isethionate salt), CAS [[827022-33-3]]

Product Overview

• Article Name: PD 0332991 Isethionate (6-acetyl-8-cyclopentyl-5-methyl-2-[ [5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d] pyrimidin-7(8H)-one isethionate salt), CAS [[827022-33-3]]
• Biozol Catalog Number: USB-145686
• Supplier Catalog Number: 145686
• Alternative Catalog Number: USB-145686-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Potent Cdk4/6 inhibitor (IC50 values are 11 and 15nm for Cdk4 and Cdk6 respectively). Selective for Cdk4/6 over a panel of 34 additional protein kinases (IC50 values are > 10um). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines, blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant. Sequence: C24H29N7O2.C2H6O4S Solubility: DMSO (~10mM), H2O (~100mM) Molecular Weight: ~573.66 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 573.66
• Purity: ~98% (HPLC)
• Form: Supplied as a yellow solid.
• CAS Number: [827022-33-3]