TAB1 (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, TGF-beta-activated Kinase 1-binding Protein 1, TAK1-binding Protein 1, MAP3K7IP1, MGC57664), R

Product Overview

• Article Name: TAB1 (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, TGF-beta-activated Kinase 1-binding Protein 1, TAK1-binding Protein 1, MAP3K7IP1, MGC57664), R
• Biozol Catalog Number: USB-146017
• Supplier Catalog Number: 146017
• Alternative Catalog Number: USB-146017-100
• Manufacturer: US Biological
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, WB
• Immunogen: Synthetic peptide corresponding to 13aa from the center of human TAB1.

Product Description

TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-b and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-b, demonstrating how this protein can function as a mediator between TGF-b receptors and TAK1. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunocytochemistry: 1ug/ml Immunofluorescence: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Cell Lysate or K562 Cell Lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Purity: Purified by immunoaffinity chromatography.
• Form: Supplied as a liquid in PBS, 0.02% sodium azide.