KDM4B (Lysine-specific Demethylase 4B, JmjC Domain-containing Histone Demethylation Protein 3B, Jumonji Domain-containing Protein 2B, JHDM3B, JMJD2B, KIAA0876), Rabbit
Biozol Catalog Number:
USB-146506
Supplier Catalog Number:
146506
Alternative Catalog Number:
USB-146506-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to 16aa from human JMJD2B.
Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A20 Cell Lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
Purified by immunoaffinity chromatography.
Form:
Supplied as a liquid in PBS, 0.02% sodium azide.
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