CK-1827452 is a diaryl urea compound that increases cardiac myosin ATPase activity in a dose-dependent manner that is selective for cardiac myosin over non-cardiac myosins. It promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP. It has been shown to increase cardiac efficiency in clinical studies of patients with chronic heart failure. Synonyms: Methyl 4-[[2-Fluoro-3-[N-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate, 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester, Omecamtiv Mecarbil CAS Number: 873697-71-3 Molecular Formula: C20H24FN5O3 Molecular Weight: 401.43 Appearance: Supplied as a white solid Purity: 97% Melting Point: 187-190C Solubility: DMSO (Slightly), Methanol (Slightly) Method for Determining Identity: Proton NMR (CD3OD, DMSO-d6), 19F NMR (CD3OD, DMSO-d6) Spectroscopic and Mass Spectrometric analysis TLC Conditions: SiO2, Dichloromethane: Methanol = 9:1, Visualized with UV and KMnO4. Single Spot, Rf=0.5. Elemental Analysis: Calculated: %C: 59.84, %H: 6.03, %N: 17.45 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
401.43
Purity:
97%
Form:
Supplied as a white solid
CAS Number:
[873697-71-3]
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