Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Brutons tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. Discovery of selective irreversible inhibitors for Brutons tyrosine kinase. ChemMedChem. 2: 58-61 (2007). Appearance: White to off-white crystalline powder Purity: 99% (HPLC) 99% (TLC) Solubility: DMSO Melting Point: 150-154C
Molecular Weight:
440.5
Purity:
99% (HPLC), 99% (TLC)
Form:
White to off-white crystalline powder
CAS Number:
[936563-96-1]
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