Selective inhibitor of TGF-beta type-I receptor (TGF-beta RI, TGFR-I, TbetaR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR-beta RI, TGF-beta RII and MLK-7K respectively). Inhibits TGF-beta-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. CAS Number: 396129-53-6 Molecular Formula: C17H12N4 Molecular Weight:: 272.3 Appearance: Very Dark Brown Solid Solubility: DMSO (Slightly, Heated) Storage: Refrigerator
Molecular Weight:
272.3
Form:
Very Dark Brown Solid
CAS Number:
[396129-53-6]
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