Tubacin, CAS [[537049-40-4]]

Product Overview

• Article Name: Tubacin, CAS [[537049-40-4]]
• Biozol Catalog Number: USB-167986
• Supplier Catalog Number: 167986
• Alternative Catalog Number: USB-167986-500,USB-167986-1,USB-167986-2.5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells. Synonyms: rel-N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N-hydroxyoctanediamide CAS Number: 537049-40-4 Molecular Formula: C41H43N3O7S Molecular Weight: 721.86 Appearance: White to off-white powder Purity (HPLC): 98% Melting Point: 155-157C Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated) Storage: -20C

Product Properties

• Molecular Weight: 721.86
• Purity: 98% (HPLC)
• Form: White to off-white powder
• CAS Number: [537049-40-4]