AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 1.3nM and 0.26nM, respectively. AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells. Synonyms: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine CAS No: 935666-88-9 Molecular Formula: C14H14ClFN8 Molecular Weight: 348.77 Appearance: White to off-white solid Purity: 98% (HPLC) Melting Point: As reported Solubility: DMSO (~70mg/ml) or Ethanol (~5mg/ml) Storage and Stability: Powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
348.77
Purity:
98% (HPLC)
Form:
White to off-white solid
CAS Number:
[935666-88-9]
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