AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide), CAS [[924416-43-3]]

Product Overview

• Article Name: AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide), CAS [[924416-43-3]]
• Biozol Catalog Number: USB-207034
• Supplier Catalog Number: 207034
• Alternative Catalog Number: USB-207034-10,USB-207034-50
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Solubility: Soluble in DMSO, 100% ethanol or methanol. Insoluble in H2O. Storage and Stability: May be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with DMSO, 100% ethanol or methanol. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Molecular Weight: 428.5
• Purity: ~98% (HPLC)
• Form: Supplied as colorless crystals.
• CAS Number: [924416-43-3]