Aftin-4 (N6-Methyl-(R)-roscovitine, Amyloid-beta Forty-Two Inducer 4), CAS [[866893-90-5]]

Product Overview

• Article Name: Aftin-4 (N6-Methyl-(R)-roscovitine, Amyloid-beta Forty-Two Inducer 4), CAS [[866893-90-5]]
• Biozol Catalog Number: USB-207035
• Supplier Catalog Number: 207035
• Alternative Catalog Number: USB-207035-1,USB-207035-5,USB-207035-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimers Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. CAS Number: 866893-90-5 Formula: C20H28N6O Solubility: DMSO or ethanol Molecular Weight: 368.5 Method for Determining Identity: Proton NMR Purity: 98% (HPLC) Appearance: Supplied as a white to off-white solid. Storage and Stability: May be stored at 4C for short-term only. Long-term storage is recommended at -20C. Stable for 1 year after receipt. Keep cool and dry. Protect from light and moisture. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 368.5
• Purity: 98% (HPLC)
• Form: Supplied as a white to off-white solid.
• CAS Number: [866893-90-5]