Antiprotozoal. Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. Induces hyperacetylation of histone H4. Apoptosis inducer. Potent anti-angiogenic compound. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells. Promotes either self-renewal or differentiation of embryonic stem cells. Synonyms: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl], OSI-2040 CAS Number: 183506-66-3 Source: Fusarium sp. Formula: C34H49N5O6 Solubility: Ethanol or DMSO Molecular Weight: 623.8 Appearance: Supplied as a white to off-white solid. Purity: 98% (HPLC, TLC) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
623.8
Purity:
98% (HPLC, TLC)
Form:
Supplied as a white to off-white solid.
CAS Number:
[183506-66-3]
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