Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A), CAS [[104987-12-4]]
Biozol Catalog Number:
USB-207066
Supplier Catalog Number:
207066
Alternative Catalog Number:
USB-207066-1,USB-207066-5,USB-207066-25
Manufacturer:
US Biological
Category:
Biochemikalien
Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Synonyms: Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A CAS Number: 104987-12-4 Source: Streptomyces sp. Formula: C43H69NO12 Solubility: DMSO or ethanol Molecular Weight: 792.0 Identity: Determined by MS and IR. Purity: 98% Appearance: Supplied as a white to off-white solid. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
792
Purity:
98%
Form:
Supplied as a white to off-white solid.
CAS Number:
[104987-12-4]
* VAT and and shipping costs not included. Errors and price changes excepted
