| Bafilomycin A1 is a member of a potent family of macrocyclic lactones with a broad spectrum of biological activity including activity against bacteria, yeast, fungi, nematodes, insects and antitumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase. Related to: Bafilomycin B1, Bafilomycin C1, Concanamycin A. Source: Streptomyces griseus Synonyms: 21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Oxacyclohexadecane, hygrolidin deriv., (-)-Bafilomycin A1, NSC 381866, [7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-8-Hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one CAS No: 88899-55-2 Molecular Formula: C35H58O9 Molecular Weight: 622.8 Purity (HPLC): 98% Appearance: Supplied as an off-white solid Solubility: Soluble in DMSO, 100% ethanol or methanol Method for Determining Identity: Proton NMR Spectroscopic Analysis Storage and Stability: May be stored at 4C for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Vortex before use. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures. |
