Borrelidin (Treponemycin, U 78548, C2989), CAS [[7184-60-3]]

Product Overview

• Article Name: Borrelidin (Treponemycin, U 78548, C2989), CAS [[7184-60-3]]
• Biozol Catalog Number: USB-207093
• Supplier Catalog Number: 207093
• Alternative Catalog Number: USB-207093-500,USB-207093-1,USB-207093-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Macrolide antibiotic. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50=0.8nM). Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Antimalarial. Synonyms: Treponemycin, U 78548, C2989 CAS Number: 7184-60-3 Source: Streptomyces sp. Formula: C28H43NO6 Method for Determining Identity: Proton NMR Solubility: DMSO or methanol Molecular Weight: 489.6 Purity: 98% (HPLC) Appearance: White to off-white powder. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 489.6
• Purity: 98% (HPLC)
• Form: Supplied as a white to off-white powder.
• CAS Number: [7184-60-3]