Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. CAS Number: 4311-88-0 Alternate Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Molecular Formula: C13H13N3OS Solubility: DMSO, ethanol or dimethylformamide. Sparingly soluble in aqueous buffers. For a maximum solubility in aqueous buffers, 207297 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. The solubility is ~0.5mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). Store aqueous solutions not longer than one day. Note: In solution the product slightly tautomerizes. In polar solvents there is more enol form while in non-polar solvents there is more keto form. Molecular Weight: 259.3 Purity: 98% (HPLC) Appearance: Off-white to yellow solid. Storage and Stability: Store at -20C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
259.3
Purity:
98% (HPLC)
Form:
Supplied as an off-white to yellow solid.
CAS Number:
[4311-88-0]
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