Acidic Mammalian Chitinase Inhibitor, Bisdionin F, CAS [[917877-86-2]]
Biozol Catalog Number:
USB-217138
Supplier Catalog Number:
217138
Alternative Catalog Number:
USB-217138-5
Manufacturer:
US Biological
Category:
Biochemikalien
A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50=0.92uM and Ki=0.42uM for hAMCase, and IC50=2.2uM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice. Synonyms: 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione, AMCase Inhibitor Formula: C16H18N8O4 Molecular Weight: 386.4 Solubility: DMSO (5mg/ml, clear, nearly colorless solution) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
386.37
Purity:
95% (HPLC)
Form:
Supplied as an off-white powder.
CAS Number:
[917877-86-2]
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