Adenosine A1 Receptor Agonist II, CCPA ((2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine), CAS [[37739-05-2]]

Product Overview

• Article Name: Adenosine A1 Receptor Agonist II, CCPA ((2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine), CAS [[37739-05-2]]
• Biozol Catalog Number: USB-217149
• Supplier Catalog Number: 217149
• Alternative Catalog Number: USB-217149-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM, 2.3uM, 18.8uM, and 42nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts. CAS Number: 37739-05-2 Synonyms: (2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine Molecular Formula: C15H20ClN5O4 Solubility: DMSO or H2O Primary Target: A1 Primary Target Ki: 2.3nM Molar Mass: 369.8 Purity: 99% (HPLC) Appearance: White solid. Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Product Properties

• Molecular Weight: 369.8
• Purity: 99% (HPLC)
• Form: White solid.
• CAS Number: [37739-05-2]