Adenovirus Proteinase Inhibitor, NSC 37249 (2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,N'-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor), CAS
Biozol Catalog Number:
USB-217160
Supplier Catalog Number:
217160
Alternative Catalog Number:
USB-217160-10
Manufacturer:
US Biological
Category:
Biochemikalien
A sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150nM) and AVP-pVIc substrate-binding site (Ki = 400nM), blocking both AVP-pVIc active complex formation (IC50 = 140nM, [substrate] = 5uM & [pVIc] = 40uM) and catalytic activity (IC50 = 490nM, [substrate] = 5uM) without affecting trypsin or papain protease activity even at concentrations as high as 10uM. Synonyms: AVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,N-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide CAS No: 2907-88-2 Molecular Formula: C40H58N4O4S Appearance: Off-white powder Purity: 90% (HPLC) Solubility: 5% TFA in EtOH Primary Target: AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket Secondary Target: AVP-pVIc substrate-binding site Storage and Stability: Lyophilized and reconstituted products are are stable for 6 months after receipt. Store at -20C. Light sensitive. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Purity:
90% (HPLC)
Form:
Off-white powder
CAS Number:
[2907-88-2]
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