A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki=4nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki=0.087, 4.2 and 18.2uM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50=460nM in AKR1C1 overexpressing BAECs). Synonyms: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20alpha-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA CAS No: 4906-68-7 Molecular Formula: C13H9BrO3 Solubility: DMSO NMR: Conforms LC-MS: Conforms Purity: 94% (HPLC) Appearance: White solid. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
293.1
Purity:
94% (HPLC)
Form:
White solid.
CAS Number:
[4906-68-7]
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