Anaphase-Promoting Complex Inhibitor, TAME (TAME Hydrochloride), CAS [[1784-03-8]]

Product Overview

• Article Name: Anaphase-Promoting Complex Inhibitor, TAME (TAME Hydrochloride), CAS [[1784-03-8]]
• Biozol Catalog Number: USB-217180
• Supplier Catalog Number: 217180
• Alternative Catalog Number: USB-217180-50
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50=12uM. Synonyms: TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I, N2-[(4-methylphenyl)sulfonyl]-L-arginine, methyl ester, monohydrochloride CAS Number: 1784-03-8 Molecular Formula: C14H22N4O4S HCl Molecular Weight: 378.87 Solubility: DMSO (50mg/ml) Purity: 95% (HPLC) Appearance: White solid Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 378.87
• Purity: 95% (HPLC)
• Form: White solid
• CAS Number: [1784-03-8]