Casein Kinase II Inhibitor VIII (4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII)

Product Overview

• Article Name: Casein Kinase II Inhibitor VIII (4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII)
• Biozol Catalog Number: USB-217252
• Supplier Catalog Number: 217252
• Alternative Catalog Number: USB-217252-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50=32 and 46nM against CK2a and CK2a, respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50=2.6, 1.6, and 2.4uM, in A549, HCT116, and MCF-7 cultures, respectively). Formula: C18H14N2O4S Molecular Weight: 354.4 Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 354.4
• Purity: ~99% (HPLC)
• Form: Supplied as an off-white solid.