CBF beta-Runx1 Inhibitor II (Ro5-3335), CAS [[30195-30-3]]

Product Overview

• Article Name: CBF beta-Runx1 Inhibitor II (Ro5-3335), CAS [[30195-30-3]]
• Biozol Catalog Number: USB-217258
• Supplier Catalog Number: 217258
• Alternative Catalog Number: USB-217258-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM, 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Synonyms: ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) CAS No: 30195-30-3 Molecular Formula: C13H10ClN3O Molecular Weight: 259.69 Purity: 98% (HPLC) Appearance: White to off-white powder Solubility (50mg/ml): DMSO Elemental Analysis: Calculated: %C: 58.5-60.5 %H: 3.5-5.0 %N: 15-16.5 Water Content (by Elemental Analysis): 1mol Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 259.69
• CAS Number: [30195-30-3]