Cdc2-Like Kinase Inhibitor IV (KH-CB19), CAS [[1354037-26-5]]

Product Overview

• Article Name: Cdc2-Like Kinase Inhibitor IV (KH-CB19), CAS [[1354037-26-5]]
• Biozol Catalog Number: USB-217260
• Supplier Catalog Number: 217260
• Alternative Catalog Number: USB-217260-1,USB-217260-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable N-methylindolyl-enaminonitrile compound that acts as a potent, non-ATP mimetic binding and reversible inhibitor of Clk1 and Dyk1A (IC50=19.7 and 55.2nM, respectively) with moderate to excellent selectivity over Clk3 (IC50=530nM) and against 71-kinases. Shown to suppress phosphorylation of Ser/Arg-rich (SR) proteins, regulate alternative splicing and lower both full-length and alternatively spliced human tissue factor isoforms much more efficiently than Cdc2-Like Kinase Inhibitor, TG003 in HMEC-1 cells. Synonyms: (E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, Clk Inhibitor IV Molecular Formula: C15H13Cl2N3O2 Molecular Weight: 338.2 Purity: 99% (HPLC) Appearance: Off-white to light yellow solid Solubility: DMSO (50mg/ml) Method for Determining Identity: Proton NMR and Liquid Chromatography-Mass Spectrometry Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -80C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Molecular Weight: 338.2
• CAS Number: [1354037-26-5]