CDC42 Inhibitor III, ZCL278 (4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)

Product Overview

• Article Name: CDC42 Inhibitor III, ZCL278 (4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)
• Biozol Catalog Number: USB-217262
• Supplier Catalog Number: 217262
• Alternative Catalog Number: USB-217262-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable, non-cytotoxic, aqueous soluble (181uM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1h pretreatment, 50uM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50uM). Synonyms: 2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide CAS No: 587841-73-4 Molecular Formula: C21H19BrClN5O4S2 Solubility: DMSO Primary Target: CDC42 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 584.89
• Purity: ~94% (HPLC)
• Form: Supplied as a light beige solid.
• CAS Number: [587841-73-4]