CFTR Inhibitor-172 (CFTRinh-172, 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone), CAS [[307510-92-5]]

Product Overview

• Article Name: CFTR Inhibitor-172 (CFTRinh-172, 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone), CAS [[307510-92-5]]
• Biozol Catalog Number: USB-217270
• Supplier Catalog Number: 217270
• Alternative Catalog Number: USB-217270-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~300nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5uM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. CAS Number: 307510-92-5 Formula: C18H10F3NO3S Solubility: DMSO Molecular Weight: 409.4 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 409.4
• Purity: 95% (HPLC)
• Form: Supplied as a yellow solid.
• CAS Number: [307510-92-5]