Choline Kinase-a Inhibitor CK37, CAS [[1001478-90-5]]
Biozol Catalog Number:
USB-217274
Supplier Catalog Number:
217274
Alternative Catalog Number:
USB-217274-5
Manufacturer:
US Biological
Category:
Biochemikalien
A cell-permeable, non-Hemicholinium-3 derivative and choline-competitive choline kinase-a inhibitor. It is demonstrated to inhibit endogenous choline kinase activity, dose-dependently, between 1-10uM, and dose-dependently decrease phosphocholine concentrations, as well as levels of downstream choline metabolites, including phosphatidylcholine and phosphatidic acid in HeLa cells. At 10uM, it is also shown to attenuate MAPK and PI3K/AKT signaling, and disrupt the actin cytoskeleton and membrane ruffling, consistent with siRNA choline kinase-a transfection. This compound exhibits dose-dependent suppression of cell growth in six tumor cell lines (IC50=5-10uM), in vitro. Furthermore, it is shown to suppress tumor growth in a mouse model by 48% at 0.08mg/g daily dose for 8 days without obvious toxicity, in vivo. CAS No: 1001478-90-5 Molecular Formula: C20H22N4OS Molecular Weight: 366.5 Purity: 97% (HPLC) Appearance: Tan powder Solubility: DMSO Method of Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at 4C. Do not freeze. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
366.5
CAS Number:
[1001478-90-5]
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