CXCR2 Antagonist, Cpd 19 (CXCR2 Inhibitor, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide), CAS [[473728-67-5]]

Product Overview

• Article Name: CXCR2 Antagonist, Cpd 19 (CXCR2 Inhibitor, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide), CAS [[473728-67-5]]
• Biozol Catalog Number: USB-217297
• Supplier Catalog Number: 217297
• Alternative Catalog Number: USB-217297-2
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37C). CAS Number: 473728-67-5 Formula: C18H21N3O4 Molecular Weight: 343.38 Solubility: DMSO (50mg/ml, light brown solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 343.38
• Purity: 95% (HPLC)
• Form: Supplied as an off-white solid.
• CAS Number: [473728-67-5]