Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldihydrocinnamoyl cyclopamine, Shh Signaling Antagonist II), CAS [[306387-90-6]]

Product Overview

• Article Name: Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldihydrocinnamoyl cyclopamine, Shh Signaling Antagonist II), CAS [[306387-90-6]]
• Biozol Catalog Number: USB-217304
• Supplier Catalog Number: 217304
• Alternative Catalog Number: USB-217304-100
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay, 50nM in p2Ptch-/-cells, 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Synonyms: 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II CAS No: 306387-90-6 Molecular Formula: C44H63N3O4 Primary Target: Hh signaling in Shh-light2 assay Primary Target IC50: 20nM Secondary Target: in P2Ptch-/-cells (IC50 = 50nM) Solubility: DMSO, EtOH, or MeOH Molecular Weight: 698 Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 698
• Purity: 70% HPLC (sum of two isomers)
• Form: Supplied as a pale yellow solid.
• CAS Number: [306387-90-6]