A cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5uM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells. Synonyms: N-((E)-(2-Hydroxynaphthalen-1-yl)methylidene)-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide, (E)-N-((2-Hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide, DIVision Inhibitor Molecular Formula: C22H20N4O2 Solubility: DMSO Primary Target: bacteria Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
95% (HPLC)
Form:
Supplied as a yellow powder.
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