DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1-(5-chloro-2-fluorobenzyl)-2,2,5-trioxospiro(indole-3,3-pyrrolidin)-1(2H)-yl)acetic Acid)
DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1-(5-chloro-2-fluorobenzyl)-2,2,5-trioxospiro(indole-3,3-pyrrolidin)-1(2H)-yl)acetic Acid)
DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1-(5-chloro-2-fluorobenzyl)-2,2,5-trioxospiro(indole-3,3-pyrrolidin)-1(2H)-yl)acetic Acid)
Biozol Catalog Number:
USB-217324
Supplier Catalog Number:
217324
Alternative Catalog Number:
USB-217324-2
Manufacturer:
US Biological
Category:
Biochemikalien
The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 5.3 and 5.0nM against human & murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I, but less oral bioavailability in mice. Synonyms: CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1-(5-chloro-2-fluorobenzyl)-2,2,5-trioxospiro(indole-3,3-pyrrolidin)-1(2H)-yl)acetic acid Molecular Formula: C20H13Cl2FN2O5 Solubility: DMSO Primary Target: DP2 Primary Target Ki: 5.3nM Molar Mass: 451.23 Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
451.23
Purity:
93% (HPLC)
Form:
Supplied as a white powder.
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