EphA Antagonist (4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid, EphA2 Antagonist, EphA4 Antagoinst, Ephrin Receptor Antagonist, Rtk2 Antagonist, Rtk1 Antagonist)

Product Overview

• Article Name: EphA Antagonist (4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid, EphA2 Antagonist, EphA4 Antagoinst, Ephrin Receptor Antagonist, Rtk2 Antagonist, Rtk1 Antagonist)
• Biozol Catalog Number: USB-217341
• Supplier Catalog Number: 217341
• Alternative Catalog Number: USB-217341-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding. Shown to inhibit ephrin-A1-induced EphA2 phosphorylation (by 92% at 200uM) and ephrin-A5-induced EphA4 phosphorylation (by 79% at 400uM) in cultures in vitro and prevent ephrin-A5-induced growth cone collapse of neurons in 6-d chicken embryo retina (by 100% at 400uM) ex vivo, as well as rescue human mutant SOD-1 A4V transgene-induced axonopathy in zebrafish embryos (500uM from 6 to 30hpf) in vivo. Solubility: DMSO Primary Target: EphA Primary Target IC50: 3 micro Molar Mass: 231.25 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 231.25
• Purity: ~95% (HPLC)
• Form: Supplied as an orange powder.