TCS ERK 11e (TCS Extracellular Signal-Related Kinase 11e, VX-11e, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide), CAS [[896720-20-0]]

Product Overview

• Article Name: TCS ERK 11e (TCS Extracellular Signal-Related Kinase 11e, VX-11e, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide), CAS [[896720-20-0]]
• Biozol Catalog Number: USB-217345
• Supplier Catalog Number: 217345
• Alternative Catalog Number: USB-217345-10,USB-217345-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable pyrimidylpyrrole compound that acts as an active site-targeting, highly potent and selective ERK1/2 inhibitor (KI <2nM against Erk2, [ATP] = 65uM), while inhibiting GSK-3, Aurora A, Cdk2 only at much higher concentrations (KI = 395, 540, and 852nM, respectively) and exhibiting much reduced or little potency toward a panel of more than 130 other kinases (KI 1.4uM, IC50 1uM). Shown to effectively inhibit human colon carcinoma HT-29 proliferation (IC50 = 48nM) and restore EGFR inhibitor WZ4002 antiproliferation activity in WZR10 cultures (84% and no inhibition, respectively, by 100nM WZ4002 with or without 1uM Erk Inhibitor VIII co-treatment). Orally available in both mice and rats in vivo. Synonyms: VX-11e, (S)-4-(2-(2-Chloro-4-fluorophenylamino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide CAS No: 896720-20-0 Molecular Weight: 500.4 Molecular Formula: C24H20Cl2FN5O2 Solubility: DMSO, DMF, Ethanol Purity: 98% Storage and Stability: Store at 4CC under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 500.4
• CAS Number: [896720-20-0]