FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl-3-yl)ester)
Biozol Catalog Number:
USB-217352
Supplier Catalog Number:
217352
Alternative Catalog Number:
USB-217352-5
Manufacturer:
US Biological
Category:
Biochemikalien
A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Formula: C20H22N2O4 Solubility: DMSO Molar Mass: 354.4 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
354.4
Purity:
95% (HPLC)
Form:
Supplied as a gray-white powder.
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