Fenobam (N-(3-Chlorophenyl)-N-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea), CAS [[57653-26-6]]

Product Overview

• Article Name: Fenobam (N-(3-Chlorophenyl)-N-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea), CAS [[57653-26-6]]
• Biozol Catalog Number: USB-217356
• Supplier Catalog Number: 217356
• Alternative Catalog Number: USB-217356-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87nM, Kd = 54nM and 31nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome. CAS Number: 57653-26-6 Molecular Formula: C11H11ClN4O2 Primary Target: mGlu5 receptors Primary Target IC50: 87nM Primary Target Ki: 54nM and 31nM at recombinant mGlu5 receptors of rat and human, respectively. Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Purity: 98% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [57653-26-6]