A potent inhibitor of dopamine active transporter (DAT, Ki = 1nM, IC50 = 40 and 51nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models. Synonyms: 1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909 CAS No: 67469-78-7 Free Base: 67469-69-6 Molecular Formula: C28H32F2N2O2HCl Molecular Weight: 450.56 (anhydrous) Purity: 98% (HPLC) Appearance: White to off-white solid Melting Point: >178C (dec.) Solubility: DMSO (Slightly), Methanol (Slightly) Primary Target: DAT Primary Target Ki: 1nM Method for Determining Identity: 1H NMR 19F NMR and Mass Spectrometric Analysis TLC Conditions: SiO2, Dichloromethane: Methanol: Ammonium Hydroxide: 9:1:0.1, Visualized with UV and KMnO4, Single spot, Rf=0.65 Elemental Analysis: Calculated: %C: 64.24, %H: 6.55, %N: 5.35 Chloride Content (Ion Chromatography): As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molecular Weight:
450.56
Purity:
98% (HPLC)
Form:
Supplied as an white to off-white solid
CAS Number:
[67469-78-7]
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