GPR109b Agonist (1-(iso-Propyl)-1H-benzotriazole-5-carboxylic Acid), CAS [[306935-41-1]]

Product Overview

• Article Name: GPR109b Agonist (1-(iso-Propyl)-1H-benzotriazole-5-carboxylic Acid), CAS [[306935-41-1]]
• Biozol Catalog Number: USB-217391
• Supplier Catalog Number: 217391
• Alternative Catalog Number: USB-217391-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable Niacin triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or b-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5uM) and isoproterenol (1uM), respectively, in GPR109b-expressing CHO cells (EC50=400nM) and freshly isolated human adipocytes (EC50 about 1uM). Formula: C10H11N3O2 Solubility: DMSO (50mg/ml), Ethanol (2mg/ml) Molecular Weight: 205.2 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 205.2
• Purity: ~98% (HPLC)
• Form: Supplied as a light brown solid.
• CAS Number: [306935-41-1]