GR 127935 Hydrochloride (5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 Hydrochloride, GR127935 Hydrochloride), CAS [[148642-42-6]]

Product Overview

• Article Name: GR 127935 Hydrochloride (5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 Hydrochloride, GR127935 Hydrochloride), CAS [[148642-42-6]]
• Biozol Catalog Number: USB-217397
• Supplier Catalog Number: 217397
• Alternative Catalog Number: USB-217397-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8) and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behavior in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97pM. Synonyms: 5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride CAS No: 148642-42-6 Molecular Formula: C29H31N5O3HCl Solubility: H2O Primary Target: 5-HT1B/1D Purity: 98% (HPLC) Appearance: Off-white solid. Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Purity: 98% (HPLC)
• Form: Off-white solid.
• CAS Number: [148642-42-6]