GSK-3beta Inhibitor XXIV (2-Methyl-5-(3-[4-(methylsulfinyl)phenyl)-1-benzofuran-5-yl)-1,3,4-oxadiazole, Racemic), CAS [[1005201-24-0]]

Product Overview

• Article Name: GSK-3beta Inhibitor XXIV (2-Methyl-5-(3-[4-(methylsulfinyl)phenyl)-1-benzofuran-5-yl)-1,3,4-oxadiazole, Racemic), CAS [[1005201-24-0]]
• Biozol Catalog Number: USB-217402
• Supplier Catalog Number: 217402
• Alternative Catalog Number: USB-217402-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

An orally bioavailable and blood-brain-barrier permeable oxadiazolo-benzofuranylphenylsulfoxide compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3b (IC50=35nM, 34 and 140nM for racemic, (S)-9b eutomer and (R)-9b distomer). The (S)-9b eutomer displays excellent selectivity (IC50 > 10uM) over Cdk1/2/5, Chk1, p38a, JNK1, MEKK1, IKKb, PKCth, CK1d, EGFR, ErbB2, Src, Lck, IR, Tie2, c-Kit, c-Met, VEGFR2, FGFR3 and PDGFRa/b, and lowers tau phosphorylation at GSK-3b-Thr205 in a CWS (cold water stress) mouse model (3mg/kg, p.o.) CAS Number: 1005201-24-0 Formula: C18H14N2O3S Solubility: DMSO or EtOH Molecular Weight: 338.4 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 338.4
• Purity: ~98% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [1005201-24-0]