GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone), CAS [[306974-70-9]]

Product Overview

• Article Name: GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone), CAS [[306974-70-9]]
• Biozol Catalog Number: USB-217408
• Supplier Catalog Number: 217408
• Alternative Catalog Number: USB-217408-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. CAS Number: 306974-70-9 Formula: C27H25FN4O4S Solubility: DMSO Molecular Weight: 520.6 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 520.6
• Purity: ~97% (HPLC)
• Form: Supplied as a white powder.
• CAS Number: [306974-70-9]