Herg Activator (NS1643, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea, Human ether-a-go-go related gene (hERG) K+ channel activator, KV11.1 Channel Activator), CAS [[448895-37-2]]
Biozol Catalog Number:
USB-217419
Supplier Catalog Number:
217419
Alternative Catalog Number:
USB-217419-10
Manufacturer:
US Biological
Category:
Biochemikalien
A diphenolurea compound that selectively activates human ether-a-go-go-related gene (hERG) K+-channel (EC50=10.5uM). Shown to significantly increase both steady-state and peak tail currents of hERG channels, but exhibits only a trivial effect on Kv4.3 and Kv1.5 channels. Causes a significant reduction in action potential duration (APD90) in patch clamp assays in Xenopus oocytes, HEK293 cells, and guinea pig cardiamyocyes that can be reversed by the addition of E-4031, a specific blocker of hERG channels. Also shown to activate IKr channel in cardiomyocytes and increase post-repolarization refractory time thereby alleviating hyper-excitability and producing antiarrhythmic effects. It can also restore IKr reduced by down-regulation of IKr expression. Synonyms: Human ether-a-go-go related gene (hERG) K+ channel activator, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea, NS 1643, KV11.1 Channel Activator CAS Number: 448895-37-2 Molecular Formula: C15H10F6N2O3 Molecular Weight: 380.2 Solubility: DMSO (100mg/ml, clear, nearly colorless solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
380.2
Purity:
97% (HPLC)
Form:
Supplied as an off-white powder.
CAS Number:
[448895-37-2]
* VAT and and shipping costs not included. Errors and price changes excepted
